Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0023015
Disease: Language Disorders
Language Disorders 		0.310 Biomarker group GENOMICS_ENGLAND [Transudative bile peritonitis in the elderly]. 516625 1979
CUI: C0233514
Disease: Abnormal behavior
Abnormal behavior 		0.310 Biomarker phenotype GENOMICS_ENGLAND [Transudative bile peritonitis in the elderly]. 516625 1979
CUI: C3714756
Disease: Intellectual Disability
Intellectual Disability 		0.310 Biomarker group GENOMICS_ENGLAND [Transudative bile peritonitis in the elderly]. 516625 1979
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder 		0.300 Biomarker disease GENOMICS_ENGLAND [Transudative bile peritonitis in the elderly]. 516625 1979
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.600 Biomarker disease PSYGENET Our findings thus suggest that heterozygous constitutive deletion of Nurr1 results in a restricted phenotype characteristic of schizophrenia symptomatology, which primarily relates to motor activity, sensorimotor gating and responsiveness to the psychomimetic drug MK-801. 21545404 2011
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.600 Biomarker disease PSYGENET Evidence by others support this hypothesis (1) mapping of the NR4A2 gene to chromosome 2q22-23, a region with suggestive linkage to schizophrenia and (2) identification of mutations in patients with schizophrenia (c.366-369delTAC, c.308A > G, c.-469delG), manic depression (c.289A > G), and familial Parkinson's disease (c.-291delT, c.-245T > G). 15211629 2004
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.600 Biomarker disease PSYGENET These data show a deficient prefrontal NGFI-B and Nurr1 expression in schizophrenia and bipolar disorder. 16631355 2006
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.600 Biomarker disease PSYGENET This suggests that the Nurr1 mutant mouse may be a potential animal model for studies on some of the behavioral and molecular mechanisms underlying schizophrenia. 17457314 2007
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.600 Biomarker disease PSYGENET The nuclear receptor Nurr1 functions to regulate dopamine neurotransmission, as Nurr1-null heterozygous (+/-) mice have alterations in dopamine function and, when raised in isolation immediately after weaning, have disruptions in sensorimotor gaiting, a behavior altered in schizophrenia and modulated by dopamine neurotransmission. 18655117 2008
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.340 Biomarker disease PSYGENET These data show a deficient prefrontal NGFI-B and Nurr1 expression in schizophrenia and bipolar disorder. 16631355 2006
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.330 Biomarker disease PSYGENET Polymorphisms in the regulatory region of Nurr1 are implicated in pathogenesis of alcohol dependence and the Nurr1/dopamine signaling pathway might be important for this dependence development in Mexican Americans. 23066323 2012
CUI: C0009171
Disease: Cocaine Abuse
Cocaine Abuse 		0.310 Biomarker disease PSYGENET In the present study, we show that each of these transcription factors is robustly expressed in adult dopamine neurons in human midbrain, and that cocaine abuse is associated with a significant decrease in the abundance of Nurr1 and Pitx3 in these cells. 15094491 2004
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.310 Biomarker disease PSYGENET Nurr1 protein in BA 9 was significantly lower in major depression (P<0.05) and lower at a trend level in schizophrenia (P=0.056) than in the controls. 16631355 2006
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.310 Biomarker disease PSYGENET Nurr1 protein in BA 9 was significantly lower in major depression (P<0.05) and lower at a trend level in schizophrenia (P=0.056) than in the controls. 16631355 2006
CUI: C0242422
Disease: Parkinsonian Disorders
Parkinsonian Disorders 		0.110 Biomarker group HPO
CUI: C0009806
Disease: Constipation
Constipation 		0.100 Biomarker phenotype HPO
CUI: C0011168
Disease: Deglutition Disorders
Deglutition Disorders 		0.100 Biomarker group HPO
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.100 Biomarker disease HPO
CUI: C0013362
Disease: Dysarthria
Dysarthria 		0.100 Biomarker disease HPO
CUI: C0013421
Disease: Dystonia
Dystonia 		0.100 Biomarker phenotype HPO
CUI: C0026837
Disease: Muscle Rigidity
Muscle Rigidity 		0.100 Biomarker phenotype HPO
CUI: C0037317
Disease: Sleep disturbances
Sleep disturbances 		0.100 Biomarker phenotype HPO
CUI: C0040822
Disease: Tremor
Tremor 		0.100 Biomarker phenotype HPO
CUI: C0085606
Disease: Urgency of micturition
Urgency of micturition 		0.100 Biomarker disease HPO
CUI: C0233565
Disease: Bradykinesia
Bradykinesia 		0.100 Biomarker phenotype HPO